Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Ali, Nurliana Binti
- Pharmaceutical Excipient Behaviour of Chickpea (Cicer arietinum) Starch in Losartan Potassium Fast Disintegrating Tablet
Abstract Views :150 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode, IN
2 Lincoln University College, Petaling Jaya,, MY
3 School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur,, MY
1 Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode, IN
2 Lincoln University College, Petaling Jaya,, MY
3 School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur,, MY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 637-643Abstract
The aim and objective of the research work is to find out the suitability of starch extracted from Chickpea (Cicer arietinum) as super disintegrant in Losartan Potassium Fast Disintegrating Tablet. The study includes preformulation characterization of starch extracted from Chickpea (Cicer arietinum) and its compatibility with drug Losartan potassium and other excipients of the formulation. Compatibility of formulation ingredients were observed by using Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC) studies. The disintegrant activity of Chickpea (Cicer arietinum) is compared parallely with the disintegrant crospovidone. Losartan potassium fast disintegrating tablet (LCP01, LCP02 and LCP03) were formulated with crospovidone and Losartan potassium fast disintegrating tablet (LCS01, LCS02, LCS03. LCS04, LCS05, LCS06) were formulated with chickpea starch as disintegrant. Physicochemical characterisation of formulated Losartan potassium fast disintegrating tablets was performed to find out the better formulation.Keywords
Chickpea (Cicer arietinum), Disintegrant, Derived Properties, Theogram, Dissolution.
References
- John C Carter,The role of disintegrants in solid oral dosage manufacturing, Carter Pharmaceutical Consulting, Inc., 2002-2006.
- Ramu. G, Mohan. G.K , Jayaveera K.N, Suresh N, Prakash C, Ramesh B. Evaluation of Abelmoschus starch as tablet disintegrant, India Journal of Natural Products and Resources, 2010; 1(3):342-347.
- Isah AB, Olorunsola EO, Zaman Y. Physiochemical properties of Borassus Aethiopum starch, Asian Journal of Pharmaceutical and clinical research, 2012; 5(3):132-134.
- Nitalikar MM, SakarkarDM, Formulation development and characterization of fast disintegrating tablets of Nimesulide, Stamford Journal of Pharmaceutical Sciences, 2011; 4(2):25-28.
- Indhumathi D, Prabha KS, Formulation and evaluation of oral dissolving tablet of Fluoxetine using super disintegrants, International Journal of Pharma and Bio Sciences, 2011; 2(1):833-847.
- Sean CS. The Complete Drug Reference, 34th Edition, London, England, UK: Pharmaceutical Press; 2011.
- Housler O, Rein H, Kerstin Laures, Lubricant sensitivity of starch based disintegrants, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology atLissabon: april-2014.
- Polesi L.F, SarmentoS.B.S, Anjos, C.B.P.Composition and characterization of pea and chickpea starches.Brazil: Brazilian Journal of Food Technology, 2011; 14(1): 74-81.
- Frimpong A, A study of chickpea (Cicerarietinum L.) seed starch concentration, composition and enzymatic hydrolysis properties. Saskatchewan: Adams Frimpong; 2010